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Lesions are typically subcortical in thecerebral hemispheres and have a predilection for theparieto-occipital regions (Chimella, 2001; Gyure, 2005).Microscopic examination shows foci of demyelinationwith surrounding infected enlarged and hyperchro-matic oligodendroglial nuclei. Thismeans that using “only” 4–5 ml/kg of tidal vol-ume (Vt) during conventional ventilation mightbe inappropriately high and is likely to causesecondary lung injury. The layers or tunics ofthe blood vessel wallsare labeled in the upper twopanels.The arrangement ofthe microcircula-tory bed incertain parts ofthe body isshown inthe lowest panel. These com-parisons have included near versus far carotid walland individual carotid segments (ie, common carotid,carotid bulb, internal carotid arterial segments) (8).Additionally, published epidemiologic studies haveused different protocols, reporting maximum thick-ness or mean thickness over the length of a carotidarterial segment or multiple segments (8)

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